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The goal is long-term metabolic balance, not short-term restriction, so your results last
Research suggests that without protective measures, approximately 2030% of weight lost during energy restriction may come from lean body mass, though this varies considerably between individuals

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risks, including the consequences of further loss of lean mass, especially in frail, sarcopenic patients

Specific to cardiovascular-related death, ELIXA and SUSTAIN-6 trials showed similar performance relative to the placebo [ HR = 0.98 (95% CI 0.781.22) and HR = 0.98 (95% CI 0.651.48), respectively]

Initial nonadherence, primary failure and therapeutic success of metformin monotherapy in clinical practice
