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Alvarez E, Roncero I, Chowen JA, Thorens B, Blazquez E

No Insurance for Your GLP-1s

5a,b), suggesting that metformin might upregulate PKA signalling via GLP-1R-independent pathway

And GLP-1s may hold even more promise for other chronic illnesses

doi: 10.1210/jc.2015-2725

In the Study of Tirzepatide in Participants with Heart Failure with Preserved Ejection Fraction with Obesity (SUMMIT) trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62
