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For example, constipation rates in clinical trials were higher with weight management doses of semaglutide (Wegovy) compared to diabetes doses (Ozempic)
The endogenous and engineered disulfide bonds are shown with solid and dashed orange lines, respectively
Whats worth knowing regardless: the drugs that started as diabetes medications and became weight loss medications may turn out to have a third significant clinical domain in psychiatry and the fact that GLP-1 receptors exist throughout the brain has been reshaping how researchers think about appetite, reward, impulsivity, and mood as genuinely interconnected rather than parallel systems
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[DOI] [PubMed] [Google Scholar] 216.Mitchell LJ, Ball LE, Ross LJ, Barnes KA, Williams LT
