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CBO notes that some analyses of weight loss via GLP-1s found they reduced all-cause mortality in certain patients, while other methods had mixed results notably bariatric surgery, which did not clearly lower future health spending and was heavily dependent on individual adherence to post-surgery lifestyle changes
The link is also in the show notes

Improved Glucose Regulation :some text Insulin Secretion : Semaglutide and tirzepatide enhance insulin secretion in response to meals, which helps to improve insulin resistance and lower blood glucose levels

Participants on tirzepatide and retatrutide have seen improvements in blood sugar levels, blood pressure, and cholesterol

Then, they compare outcomes between patients with 2018 providers who were high- and low-adopting practitioners

Also important: many people find that these symptoms improve after the body adapts (usually weeks 48)
