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Some investigators have proposed that GLP-1RAs improve myocardial insulin sensitivity, enhance glucose oxidation rates, reduce fatty acid oxidation, and thereby optimize myocardial energy metabolism, ultimately improving cardiac function.106 In a randomized controlled trial (RCT) conducted by Mikhail et al,106 semaglutide efficacy was evaluated in 616 patients with obesity-related heart failure and T2DM

Guldemir HH, Buyukuslu N, Yigit P, Cakici C, Ozdemir EM

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GLP1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NFB signaling pathways in streptozotocininduced diabetic rats