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In the present study using obese mice fed HFD for 5 weeks or longer, food intake in LP (7:3019:30) was approximately doubled, whereas that in dark period (DP, 19:307:30) unaltered, exhibiting LP-specific hyperphagia accompanied by daily hyperphagia (Figs

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In PWA mice, metformin therapy caused very modest metabolic effects (Fig

As shown in Table 4 , lixisenatide exhibited the most noteworthy association with hypoglycemia adverse effects, owing to its highest ROR, PRR, and empirical Bayesian geometric mean (EBGM), followed by exenatide, dulaglutide, liraglutide, and semaglutide