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Although the study reports that the majority of these were mild/moderate (and only 4.5% discontinued treatment due to GI side effects) you do wonder if this had an impact on the weight loss

CEN Case Rep (2021) 10(1):425

B., Newmeyer, M

With regard to adverse effects, gastrointestinal intoleranceespecially nausea and vomitingrepresents the class-defining limitation

Roberts VL, Stewart J, Issa M, et al

- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1, NEJM 2021, n=1,961) Symptoms | The Menopause Society What Real Users Say About Seeing Symptoms in Context A Changed Body Deserves a Record, Not a Guessing Game One App Store reviewer, TheVideoGamerGirl, wrote: That is the whole idea applied to cycle changes, heat, and fatigue: when symptoms sit beside the dose timeline, the rough days stop being random