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The triple-incretin pharmacology represents an attempt to combine the insulin-sensitizing and appetite-modulating effects of GLP-1/GIP agonism with the energy-expenditure effects of glucagon receptor activation

With a high degree of efficacy and a low side effect profile, semaglutide is an incredibly useful medication for patients with type 2 diabetes or obesity they want to control medically

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Some are now FDA-approved for chronic weight management, including semaglutide 2.4 mg (Wegovy), tirzepatide (Zepbound), and liraglutide 3 mg (Saxenda)

Glucagon, from past to present: a century of intensive research and controversies