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Obesity carries a fivefold associated risk of development of cardiometabolic disease (e.g., coronary artery disease, stroke, type II diabetes mellitus) 2

On the flip side, the normalization of using medication for weight management could reduce stigma around obesity as a solely lifestyle issue, reinforcing that biological factors are at play and medical help is legitimate

New Drug Retatrutide Shows Benefits for Diabetes and Weight Loss Results from recent clinical trials suggest that retatrutide, a first-of-its-kind experimental drug, causes unprecedented levels of weight loss

In a study of 3596 patients (20% males, mean age 43.5 years) receiving sleeve gastrectomy or Roux-en-Y gastric bypass surgery followed for 3-years it was found that the highest rate of loss in FFM occurred at 3- and 6-months (57% and 78% of peak loss) post-surgery, with higher preoperative BMI one of the key factors associated with greater FFM loss [11]

Its approved for type 2 diabetes by the FDA, but some doctors may prescribe it off label for obesity

The effects of GLP-1 infusion in the hepatic portal region on food intake