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The glucagon-like peptide-1 receptor (GLP-1R) is a key target for diabetes mellitus (DM) treatment, and GLP-1R agonists are pharmaceutical compounds employed in the treatment of DM

Similar to other antidiabetic medications, such as metformin [40], and in combination with diet and exercise, the reduction in insulin resistance induced by GLP-1 RAs may help reduce or resolve AN

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Table of Contents Retatrutide and Diarrhoea: What the Evidence Shows Phase 2 trial data confirm diarrhoea is a common adverse effect of retatrutide, driven largely by its GLP-1 receptor agonist component, which slows gastric emptying and alters intestinal transit