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Important context: oral semaglutide is a GLP-1 receptor agonist only

5-HT2B: fluoxetine (5200) and sertraline (2200), with most SSRIs showing minimal affinity

Including insulin resistance, leptin insensitivity, and downregulated GLP-1 secretion
One such study by McClean and colleagues [61] observed that liraglutide can cross the blood-brain barrier in substantial amounts and can prevent deficits in the water maze task performance and object recognition in AD model mice

Given these complexities, CBO acknowledges a lot of uncertainty involved in these calculations
