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Effects of Tirzepatide, a dual GIP and GLP-1 RA, on lipid and metabolite profiles in subjects with type 2 diabetes

They group also established protocols for incorporating these activated aza-amino acids demonostrating the can employ their methodology to systematically modify individual amino acids in peptides via an aza-scan approach, generating a small library of aza-amino acid-substituted peptide analogues for further biological evaluation

Clinical trials have applied the GIPET technology to several peptides and proteins (Table S1)

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Despite extensive sequence identity, only some snake venom metalloproteinases (SVMPs) bind collagen IV and have haemorrhagic activity