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Buse JB, Bain SC, Mann JFE, Nauck MA, Nissen SE, Pocock S, et al

Among the individual trials, the strongest benefit signals were seen with efpeglenatide and subcutaneous semaglutide, which lowered rates of MACEs by 27% (HR 0.73, 95% CI: [0.58, 0.92]) [59] and 26% (HR 0.74, 95% CI: [0.58, 0.95]) [50], respectively (Table 2)

This situation has prompted the next leap: can we deliver GLP-1 therapy in monthly injections to improve patient experience and long-term adherence

Indicator #1 Unprecedented Growth: GLP-1 Products Redefine Revenue Trajectories (FIGURE 1) Since launch, GLP-1 drugs have generated a cumulative $71 billion in US revenue and they are projected to amass $400 billion more in the coming years to reach $470 billion by 2030