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We've never had a single serious side effect at all in our program, but at this point, truly we hardly have people with nausea, GI upset

Sun et al., with RT-PCR studies on Rag1 / DSS colitis mice (which lack T and B cells) treated with liraglutide, demonstrated the significant upregulation of the following IL-22-dependent genes: Ltbr, Il18, and RegIII, while the expression of Glp1r, Tjp1 (encoding the tight junction protein ZO-1), and Il23 remained unchanged

Interestingly, bile acid metabolites have a dual effect on GLP-1 secretion: they can both stimulate and inhibit its production (66)