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Clinical studies have demonstrated that people who take Semaglutide GLP-1 injections along with making lifestyle changes, such as healthy eating and exercise, can lose a significant amount of weight over time

The specific criteria for inclusion and exclusion of relevant studies in terms of PI(E)COS (Population, Intervention/Exposure, Comparison, Outcomes, and Study design) are provided in Table 1

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Studies have shown that GLP-1R agonists are also able to reduce myocardial infarction, stroke and heart failure (Solini et al., 2023