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Similar findings were also described in the EAE model, with increased intestinal permeability, reduced submucosal thickness, and altered TJ expression in IECs, which have been associated with a mucosal imbalance between Th1/Th17 and Treg cell subsets in intestinal lamina propria, Peyers patches, and mesenteric lymph nodes (41, 246)
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The FDA requires stopping GLP-1 medications at least two months before attempting pregnancy due to animal studies showing potential fetal harm
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