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These compounds work through entirely different mechanisms, making direct comparison difficult

Methods: A structured narrative review of clinical trials, real-world observational studies, and contextual cardiovascular outcome analyses was conducted

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Supplemental Table 2), indicating that the pattern of change in appetite before and after the drinking session differed between groups

Tesamorelin may produce faster changes in body composition, while sermorelin provides gradual, long-term improvements in hormone balance and vitality

The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo