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In contrast, semaglutide demonstrates weight reductions of 1015% or more in the same timeframe, with some patients achieving 20%+ loss at higher doses

Diabetologia 36, 741744

Steady state still takes 4-5 weeks

What to discuss with your provider Be direct about your goals

At the time of diagnosis of clinical ASCVD in a patient with T2D on a drug regimen that does not include a GLP-1 RA or an SGLT-2 inhibitor with demonstrated cardiovascular benefit

In a study of 3596 patients (20% males, mean age 43.5 years) receiving sleeve gastrectomy or Roux-en-Y gastric bypass surgery followed for 3-years it was found that the highest rate of loss in FFM occurred at 3- and 6-months (57% and 78% of peak loss) post-surgery, with higher preoperative BMI one of the key factors associated with greater FFM loss [11]