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Furthermore, co-injection of exendin (939) with teneligliptin partially reversed allodynia, but not tail-flick latency, suggesting GLP-1R-independent mechanisms [70]

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When to Seek Medical Support and Personalized Dose Management Contact your healthcare provider if diarrhea persists beyond 12 weeks of stable dosing, occurs multiple times daily with severe urgency, causes dehydration (dark urine, dizziness, extreme thirst), or contains blood or mucus

These results warrant further translational exploration of GLP-1R agonists, particularly in individuals for whom metabolic dysregulation and addiction vulnerability converge

Beyond 6 Months: Long-term studies demonstrate that these medications continue to provide sustained benefits with ongoing treatment