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However, certain GI side effectsnausea, constipation, loose stoolsmay be more pronounced or harder to distinguish from post-surgical symptoms

Hunger signals rise

Common adverse reactions include nausea, vomiting, diarrhea, and constipation

The medication also improves insulin sensitivity and stabilizes blood glucose patterns, supporting metabolic efficiency during weight loss

These patients should be followed more closely ( Table 1 )

For current regulatory timelines by country, see retatrutide availability
