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Additionally, the trials have reported potential cardiovascular effects, such as dose-dependent increases in heart rate and a small number of cardiac arrhythmia cases

Novo Nordisk has responded by planning a higher-dose CagriSema trial (REDEFINE 11), expected to report in early 2027, and by filing an NDA at the current dose

Thermogenesis and energy expenditure Glucagon receptor activation increases energy expenditure through multiple pathways

Include plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats

Long-term outlook for heartburn on tirzepatide The good news is that for most users, heartburn on tirzepatide is a temporary challenge, not a permanent condition