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Description
Understanding the lack of improved cardiovascular outcomes with GLP-1R agonists in ELIXA, EXSCEL, PIONEER 6, and FREEDOM CVOTs is complex, potentially originating from differences in trial design, variable sample sizes, discontinuation rates, follow-up durations, and challenges in achieving sustained pharmacokinetics during drug development
17 Conversely, findings from another population-based study suggested there was no overall increased risk of DR associated with GLP-1RA use, while a meta-analysis indicated albiglutide, a GLP-1RA no longer commercially available due to limited prescribing, was associated with an increased risk of early worsening (the four GLP-1RAs available did not exhibit a statistically significant association with DR)
13 June 2023
High blood sugar damages the blood vessels and nerves that supply and control the heart, decreasing its ability to pump blood effectively
High biotin levels can cause falsely low TSH readings and falsely elevated free T4, mimicking hyperthyroidism on paper
(You can purchase smaller syringes)
