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67,68 Still, the presence of GLP-1 RA-specific psychiatric adverse events that may also be related to drug intolerance requires the development of a strategy to overcome this barrier for the better implementation of GLP-1RA therapy

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The active ingredient is the same molecule

122 Interestingly, GLP-1/estrogen demonstrates a promising role in improving ovarian cyclicity in milder PCOS phenotypes with preserved ovulatory function, effectively normalizing cycle irregularities and enhancing reproductive hormonal balance, while, at lower doses, it outperformed other multi-agonists by reducing body weight (by 10%), fat mass (by 50%), and improving glucose metabolism and insulin sensitivity in PCOS models, without causing significant changes in ovarian or uterine parameters