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The medications have complementary effects on glucose control, and metformin has a long safety track record in combination with GLP-1 based agents

Paused, then restarted (June 2026 update) The dose-reduction experiment got cut short

[DOI] [PubMed] [Google Scholar] 629.Gros R., You X., Baggio L.L., Kabir M.G., Sadi A.M., Mungrue I.N

Resuming therapy after a long break If you took a long break and want to restart your medication, start at a lower dose

Medicaid prior authorization for GLP-1 therapy usually requires 4-8 weeks of waiting, with some applications taking 12+ weeks before denial or approval

Affected products The following products are examples of unauthorized injectable peptide drugs seized by Health Canada