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What weight loss results have been reported in clinical trials

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10.1016/j.bbr.2010.09.024 [DOI] [PubMed] [Google Scholar] 51.Canneva F, Golub Y, Distler J, Dobner J, Meyer S, von HS

GIP is the main incretin hormone in healthy people, causative of most the incretin effects but the insulin response after GIP secretion in T2DM is reduced [12]

MASH has replaced the old terminology of NASH (non-alcoholic steatohepatitis) and is defined as the presence of 5 % hepato-steatosis and hepatocyte "ballooning" (inflammation with hepatocyte injury and cell liver death) with or without fibrosis [5,6] [Table 2]

Triple-Hormone-Receptor Agonist Retatrutide for Obesity Weekly retatrutide injections (1 mg12 mg) resulted in weight reductions of 7.217.5% at 24 weeks and 8.724.2% at 48 weeks in subjects with overweight or obesity (without T2DM) in a phase II, double-blind, randomized, placebo-controlled [125]