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Never freeze a reconstituted solution freeze-thaw cycles structurally damage the peptide and reduce potency

Conformational cooperativity between helical domains of differing geometry in oligoamideoligourea foldamer chimeras

doi: 10.1042/bsr20203944 82 ZhouMZhaoHXuWBaoSChengLSunJ
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doi: 10.1038/s41586-023-06873-0

This followed new provisions included in the Food and Drug Omnibus Reform Act of 2022, which gave the FDA authority to improve transparency around accelerated approvals and ensure that applicants complied with post-marketing requirements
