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In a meta-analysis of 60 studies involving 60,077 T2D patients, GLP-1RAs marginally reduced the UACR in comparison to placebo and other antidiabetic agents, but resulted in no clinically relevant changes in eGFR ( Renoprotective Mechanisms of GLP-1RAs Experimental studies to elucidate the beneficial effects on DKD have been extensively reported

Such decisions should be made collaboratively with families, following a thorough discussion of the potential benefits, risks, and side-effect profiles of these medications

Some people may prefer to stick to the lower 1.7 mg per week or 2.4 mg dose as their maintenance dose

This can require counseling from nutritionists, since many patients tend to focus only on weight issues

These factors influence whether combination treatment is appropriate or contraindicated

Then there's dulaglutide, which are weekly injections