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However, there are some distinct structural features in compound 2 alone bound receptor

GLP-1 receptors are also expressed in cardiomyocytes and vascular endothelial cells, and their activation has been shown to promote myocardial glucose uptake, reduce oxidative stress, inhibit cardiomyocyte apoptosis, and improve endothelial function [[18], [19], [20]]

Flannery PJ, Trushina E

Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection

If staying at very low doses long-term worked as well, RCTs would reflect that by now