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Yes, antacids, H2-receptor antagonists, and proton pump inhibitors can generally be used safely with semaglutide to manage heartburn symptoms

K.et al (2013)

Experimental validation demonstrated that Amuc_1409 interacts with E-cadherin, leading to dissociation of the E-cadherin/-catenin complex and subsequent activation of the Wnt/-catenin signaling pathway

However, a sudden, drastic increase in fiber can sometimes lead to bloating and gas, so a gradual approach is key