glp 1 high heart rate and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference | American Journal of Physiology-Heart and Circulatory Physiology Heart Benefits of GLP-1s Disappear

Important considerations include: GLP-1 agonists are generally well-tolerated in people with hypertension They do not typically cause dangerous drops in blood pressure Dehydration from gastrointestinal side effects (nausea, vomiting, diarrhoea) can occasionally affect blood pressure and kidney function, so maintaining adequate fluid intake is important If you take diuretics (water tablets), ACE inhibitors or ARBs for blood pressure, your doctor may monitor you more closely during the initial weeks of GLP-1 therapy Seek medical advice promptly if you experience persistent gastrointestinal symptoms that prevent adequate fluid intake NICE guidance (NG28) supports the use of GLP-1 agonists in people with type 2 diabetes who meet specific criteria, with preference for agents with proven cardiovascular benefits in those with established cardiovascular disease

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Anti-emetic medications are generally not recommended as first-line treatment, as most nausea resolves with dietary adjustments and time