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Kaplan-Meier analysis (Figure 2) showed early separation of cumulative incidence curves, which progressively widened over time

A prospective cohort study involving 32 T2DM patients on metformin monotherapy or metformin plus GLP-1RA illustrated that metformin plus GLP-1RA over 24 months of therapy was superior to metformin monotherapy (Rogliani et al

In addition, with rapid weight loss on GLP-1s, along with fat loss excess muscle loss is possible

They are taken once a day and have been found to be effective for weight loss

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Adequate protein intake and appropriate supplementation can help manage energy levels during adaptation
