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The disadvantage is cost and access
Additionally, some patients reduce caffeine consumption as appetite decreases, and caffeine withdrawal is a well-documented migraine precipitant
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Schedule is 5 days on, 2 days off: every month, across a 3-month active cycle, followed by a 2-month rest before repeating
Allergic: Rash, pruritus, photosensitivity and angioedema
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