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NICE has backed use of the Wegovy (semaglutide) for people with a body mass index (BMI) of 35 kg/m2 or more and at least one weight-related ailment such as high blood pressure, high cholesterol or diabetes as part of a weight management programme involving exercise and a reduce-calorie diet.

Summary SGLT2-i exert more consistent BP-lowering effects than GLP-1RA, largely due to their diuretic-like action

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