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As a mitochondrial-derived peptide, it activates AMPK pathways associated with improved glucose metabolism and metabolic flexibility

[5] [7] A similar approach may be prudent for patients on GLP-1/GIP medicines, especially those with additional risk factors such as vegan diets, previous gastric surgery, or concurrent metformin use

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However, two studies with similar dosages (21 g/d and 20 g/d) and identical intervention periods (6 weeks) showed contradictory results as they found beneficial or no effects on anthropometric parameters, respectively [9,42]