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Research suggests roughly 30% of weight lost on GLP-1 therapy comes from lean mass, with significant variability between studies. With adequate protein intake and consistent resistance training, that proportion can be reduced

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Patients should also monitor blood glucose levels if unable to maintain adequate oral intake, especially if taking insulin or sulfonylureas, as medication adjustments may be needed to prevent hypoglycemia

Potentially negative effects of weight loss may include saggy skin throughout many areas of the body, side effects commonly referred to with names like Ozempic butt or Ozempic face, which can negatively affect appearance and self-confidence

We performed RNA-seq following 48 hrs of auxin treatment from the L1 stage at 25C, a time where LAG-1 is undetectable, and the same time point where GLP-1 ON and OFF RNA-seq was performed ( Fig 5 )
