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Description
Park MJ et al
These receptor agonists target the GLP-1R and enter the body to treat a variety of diseases
PMID 27313432
Conclusion: Cinchonine, a potential oral small-molecule GLP-1R agonist, could reduce blood glucose and ameliorate NASH, providing a strategy for developing small-molecule GLP-1R agonists
Interestingly, GLP-1Rs are abundantly expressed not only in the pancreas and gastrointestinal tract but also in other organs, such as the lung [247]
doi: 10.1016/j.lfs.2020.118731 275 TzavlakiKMoustakasA
