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Research shows that even a 4 mm needle reliably reaches the subcutaneous layer in the vast majority of adults

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Pregnancy considerations: Tirzepatide is not recommended during pregnancy, and women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during initiation and dose escalation

If you are starting a new pen or have stored your used pen in the fridge between doses, it is a good idea to take your pen out of the fridge and leave it at room temperature (not above 30oC) for 30 minutes

But controlled trials with thousands of participants provide the kind of clarity that anecdotal reports simply cannot match
