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The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at C-3 position by polar functional groups caused dramatic decline in its potency and efficacy 38

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Kabahizi A., Wallace B., Lieu L., Chau D., Dong Y., Hwang E.S., Williams K.W

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However, distinguishing between expected metabolic adjustment and problematic tiredness requires understanding individual factors including genetic background, baseline metabolic health, and nutrient status