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This genetic context may help provide insight into treatment response variability and support more informed medication selectionwhether compounded semaglutide, tirzepatide, or combination formulations
In addition, a membrane-bound zinc metallopeptidase, neutral endopeptidase 24.11 (NEP 24.11), has also been shown to cleave GLP-1 at its C terminus both in vitro and in vivo (Plamboeck et al., 2005)
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