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doi: 10.1053/j.gastro.2024.03.015

Dietary choices significantly influence bile chemistry during weight loss

Are these just anecdotes, or is there data behind them

The GIP receptor component appears to contribute meaningfully to lipid metabolism improvements, insulin sensitization in adipose tissue, and potentially cognitive and bone health effects that pure GLP-1 agonists do not provide

The ongoing coronavirus disease 2019 (COVID-19) has severely exacerbated this already worrisome trend, with the World Health Organization estimating a 25% increase in baseline stress levels globally as a consequence of the pandemic

Importantly, they can also convert indigestible carbohydrates into short-chain fatty acids (SCFA), which in turn activate specific G protein-coupled fatty acid (FFA) receptors, thereby promoting the secretion of peptide hormones from the enteroendocrine cells [106, 107]