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This structure confers a slower absorption and reduced rate of renal clearance [101]

Results GLP-1R was downregulated in the livers of NAFLD patients Recent clinical studies have shown that GLP-1R agonists represent an attractive treatment option for obese patients with NAFLD 26

These insights enhance our understanding of the broader therapeutic potential of GLP-1 agonists beyond diabetes and obesity treatment

Nonetheless, subsequent evidence indicating that the insulinstimulating effect of GIP is partially regained through enhanced glycemic management in T2DM subjects [129, 130], coupled with the emergence of new antagonists [131] suitable for clinical investigations, is prompting a reevaluation of the involvement of GIP in moderating the DPP4i treatment glycemic effects

We dont have all the evidence yet but its a pathophysiological clue worth pursuing