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Funding None of the authors received any funding for this manuscript

The most well-established hormonal effects of GLP-1 receptor agonists involve the glucose-regulatory hormone system, specifically insulin and glucagon

Access, Affordability, and Pricing Risks Perceived excessive and unjustified price increases, as well as regional cost disparities, have sparked public debate and criticism over companies pricing strategies for their GLP-1 medications

Clinical trials have not shown a signal for increased thyroid cancer risk, though regulators note that the human relevance of rodent C-cell tumours is unknown and monitoring is ongoing

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Persistent lymphadenopathy (3 weeks for neck lumps) requires GP assessment and may warrant suspected cancer pathway referral per NICE NG12