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When used alongside nutrition and lifestyle changes, GLP-1 therapies may support long-term weight-management efforts and metabolic health goals

Body recomposition without pharmaceutical assistance is theoretically possible but practically impractical for most individuals

doi: 10.1001/jama.2023.20294, 44

After 24 weeks, testosterone levels had increased in both groups, with a larger rise in the TRT group

This work expands our understanding of GLP-1R activation and provides valuable insights into potential application of ago-allosterism in drug discovery

What has become increasingly clear since 2023 is that GLP-1 receptors are also active in areas of the brain involved in reward, impulse control, motivation, and stress regulation