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Many patients remain on the 2.5 mg or 5 mg starting doses, which are primarily for tolerability rather than therapeutic effect, and do not reach the 10-15 mg weekly doses where maximal efficacy typically occurs

Dopamine, often associated with the reward and pleasure centers of the brain, plays a pivotal role in motivation and attention mechanisms

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Similar content being viewed by others 1 Introduction While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are recommended as the first injectable treatment in type 2 diabetes mellitus (T2DM), insulin still remains a cornerstone of therapy, starting with basal-only insulin and continuing to intensification with basal-bolus insulin treatment [1, 2]