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Instead, this drug interrupts signalling that could affect appetite in parts of the central nervous system that are not behind the blood-brain barrier

The risk profile is not only clinical but also regulatory , requiring vigilance at the dispensing stage

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Therefore, GLP-1RAs need to pass through the blood-brain barrier to exert their pharmacological effects

Potential Side Effects and Drug Interactions Berberine is generally considered well-tolerated in the short term, but like any bioactive compound, it can cause adverse effects and interact with medications

The semaglutide group had a higher proportion of participants experiencing gastrointestinal events leading to drug discontinuation than placebo (11.1% vs