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and increased insulin early AUC and C-peptide total and early AUCs

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Retatrutide reported up to 28.7% average weight loss and pain reduction of up to 75.8% on the WOMAC scale in adults with obesity and knee osteoarthritis [9]

Adult-onset type 1 diabetes mellitus differs from the early onset form in terms of residual endogenous insulin secretion, comorbidities and baseline cardiorenal risk

Future clinical trials should aim to distinguish the direct analgesic effects of GLP-1RAs from their metabolic benefits and explore their broader applications in pain conditions