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PLoS One 11:e0161955

Hang onto the original packaging and any inserts about temperature or handling

Siemens, MP-RAGE) was also acquired to delineate the predefined ROIs as well as to aid in preprocessing of the fMRI images

Guidance has evolved over the past few years, and current recommendations emphasize personalized decision-making rather than a one-size-fits-all approach

More plausible pathways include appetite suppression, reduced caloric intake, delayed gastric emptying, reduction in adiposity, and improvement in insulin sensitivity

When the 60 mg vial makes financial sense You are at a maintenance dose of 7.5 mg or higher (you will use the vial within the stability window) You have already titrated using smaller vials and know your target dose You are comfortable with reconstitution and precise syringe measurements You can store the vial properly for the entire duration When smaller vials make more sense You are just starting tirzepatide and do not know your dose yet You are microdosing at very low amounts (1-2.5 mg) You want to test a new vendor or batch before committing to a large purchase Your storage conditions are not ideal (unreliable refrigeration, travel) Syringe selection and measurement precision The syringe you use matters more than most people realize