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Solid-Phase Peptide Synthesis (SPPS) of: A tetrapeptide extension (Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH) A C18-fatty acid linker with Glu-2xAEEA (PEG-based) Chemical Coupling of the components via NHS/DCC activation, followed by RP-HPLC purification and lyophilization

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GLP-1 receptor agonists may be appropriate for patients with high blood pressure, though clinical monitoring and provider guidance are essential