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In a phase 2, double-blind, placebo-controlled trial of retatrutide vs placebo (NCT04881760), adults with obesity or with overweight and obesity-related complications but without diabetes who were treated with retatrutide achieved a mean weight reduction of up to 17.5 % at 24 weeks (primary endpoint) and up to 24.2 % at 48 weeks in the 12 mg group

Phillips SM, et al

Below are some details of the pharmacology of the medication that makes it such an effective weight-loss drug: GLP-1s stimulate the secretion of insulin and slow the release of glucagon, thereby keeping blood sugar low

The main difference is cost and conveniencecompounded options are significantly less expensive and available without insurance or membership fees

However, adverse effects like nausea and changes in gastric motility are not uncommon, and their persistence over time is still under investigation for laboratory research use only or equivalent
