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Exp Brain Res2009 Jul;197(1):23-34

In particular, Frssing et al

Incretin hormones also coax the food to linger in your stomach a little longer, so you feel full, and your appetite decreases two bonuses if youre trying to shed a few pounds

Eli Lilly developed tirzepatide for type 2 diabetes (Mounjaro, FDA-approved 2022) and later for chronic weight management (Zepbound, 2023)
Professional guidance prioritizes individualized titration rather than milligram-for-milligram swaps, as laid out in the ADAs 2025 Standards of Care chapter on Pharmacologic Approaches to Glycemic Treatment (diabetesjournals.org)

10.3390/ijms21072546 65 LibermanA.EsserM.MarxN.BurgmaierM
